Po-Hao Chen, MD MBA

MSK Radiology and Nuclear Medicine
Hospital of the University of Pennsylvania
About

About

Po-Hao Chen (Howard) is a musculoskeletal radiology fellow at the Hospital of the University of Pennsylvania. He received his MD and MBA from Harvard University. He will be the Associate Chief Imaging Informatics Officer at Cleveland Clinic in summer 2018.

View curriculum vitae

You can find his profile on Twitter, LinkedIn, Google+, or follow the blog Figure Stuff Out. He is also the creator of Radiology Data Quest, a data science blog focused on radiology. Howard enjoys imaging informatics, healthcare innovation, and good comfort food.

Projects

ARIES - Web-Based Bayesian Analytics for Diagnostic Support

  • Plug-and-play Bayesian "artificial intelligence" for diagnostic support and education, with real-time update of differential diagnoses.
  • Various features presented at 2016 SPIE Medical Imaging and 2018 SPIE Medical Imaging conferences
  • Educational mode presented at 2016 RSNA annual conference
  • Contributed to Bayes net research leading to additional oral presentations at ASNR, ACR, and SIIM.
  • Supported in part by an RSNA Educational grant with open-source release. Not a commercial product

    • Capricorn - Radiology Residency Analytics Tool

  • Residents: Track cases automatically for ACGME and MQSA. Discover discrepancies. Review attending changes to preliminary report. Crowdsource teaching files. (website)
  • Program Director: Curate resident performance dashboards. Identify great calls. Recognize underperformers.
  • Decreased missed PE on CTA by trainees using data-driven integrated quality improvement initiative
  • 2 peer-reviewed manuscripts on usability and on statistical analysis of attending variability.
  • RSNA oral presentations on analytics and approach to crowd-sourcing teaching files.
  • Winner of the 2014 Open Source Leadership Award at SIIM. Not a commercial product.

    • Centaur - Rapid-Fire Learning Module for Basic Imaging Findings

  • Radiology education tool. Single player "video game"-like mechanics. Rapid fire cases. Instant feedback. (website)
  • Trains perception of normal versus abnormal features.
  • 2 oral presentations at the RSNA conference.
  • Peer-reviewed manuscript showing improved trainee ability to perceive abnormality after one 20-minute session.

    • RadCare - Resident-Led Radiology Consultation for General Medicine Wards

  • Created in-person consultation service for radiology residents to integrate with general medicine teams as part of normal radiology rotation.
  • 43% of all consultations led to a change in immediate clinical management decisions.
  • Radiology residents were shown to be no less productive while on consultation compared to in reading room.
  • 2017 AUR Research Scholars award for oral presentation.

    • Integrating natural language processing and machine learning algorithms to categorize oncologic response in radiology reports

  • Created 9400 manually curated reports using structured reporting system "Code Oncology."
  • Studied the effect of NLP techniques (filter-based feature selection, N-gram tokenization, stop-word removal, word stemming, and tokenization models such as TF-IDF) on classification accuracy.
  • Compared performance of multiple machine learning algorithms on predictive accuracy.
  • Peer-reviewed manuscript published.

    • Unsupervised genomic and epigenetic analysis

  • Developed new techniques for probabilistic modeling of epigenetic relationships between miRNA, mRNA, and DNA polymorphism using differences between patient samples to bypass need for a priori data annotation.
  • Predictions validated by biochemical bench analysis.
  • Technique utilized in manuscripts published Science, Cell, Molecular Cell, and BMC Genomics.

    • Select Publications

    Curriculum Vitae

    1. Deitte LA, Chen PH, Scanlon MH, Heitkamp DE, Davis LP, Urban S, et al. Twenty-four-Seven In-house Faculty and Resident Education. Journal of the American College of Radiology. 2018 Jan;15(1):90a.
    2. Chen PH, Zafar H, Galperin-Aizenberg M, Cook T. Integrating Natural Language Processing and Machine Learning Algorithms to Categorize Oncologic Response in Radiology Reports. Journal of Digital Imaging. 2017 Oct 27 [epub ahead of print]
    3. Chen PH, Mankoff DA, Sebro RA. Clinical overview of the current state and future applications of positron emission tomography in bone and soft tissue sarcoma. Clinical and Translational Imaging. 2017 Aug;5(4):34358.
    4. Chen PH, Roth H, Galperin-Aizenberg M, Ruutiainen A, Gefter W, Cook TS. Improving abnormality detection on chest radiography using game-like reinforcement mechanics. Academic Radiology. 2017 Nov;24(11):142835.
    5. Wildenberg JC, Chen PH, Scanlon MH, Cook TS. Attending Radiologist Variability and Its Effect on Radiology Resident Discrepancy Rates. Academic Radiology. 2017 Jun;24(6):6949.
    6. Chen PH, Botzolakis E., Mohan S., Bryan R.N., Cook T. Feasibility of streamlining an interactive Bayesian-based diagnostic support tool designed for clinical practice. In: Zhang J, Cook TS, editors. Proc SPIE Medical Imaging. 2016. p. 97890C.
    7. Chen PH, Loehfelm TW, Kamer AP, Lemmon AB, Cook TS, Kohli MD. Toward Data-Driven Radiology Education - Early Experience Building Multi-Institutional Academic Trainee Interpretation Log Database (MATILDA). Journal of Digital Imaging. 2016 Mar.
    8. Chen PH, Chen YJ, Cook TS. Capricorn - A Web-Based Automatic Case Log and Volume Analytics for Diagnostic Radiology Residents. Academic Radiology. 2015 Oct;22(10):1242-51.
    9. Traeger LL, Volkening JD, Moffett H, Gallant JR, Chen PH, Novina CD, et al. Unique patterns of transcript and miRNA expression in the South American strong voltage electric eel (Electrophorus electricus). BMC Genomics. 2015;16:243.
    10. Gallant J, Traeger L, Volkening J, Moffett H, Chen PH, Novina C, et al. Genomic basis for the convergent evolution of electric organs. Science. 2014 Jun 27;344(6191):1522-5.
    11. Chen PH, Slanetz PJ. Incremental clinical value of ultrasound in men with mammographically confirmed gynecomastia. European Journal of Radiology. 2014 Jan;83(1):123-9.
    12. Kung JW, Slanetz PJ, Chen PH, Lee KS, Donohoe K, Eisenberg RL. Resident and Attending Physician Attitudes Regarding an Audience Response System. Journal of the American College of Radiology. 2012 Nov;9(11):828–31.
    13. Chen PH, Ghosh ET, Slanetz PJ, Eisenberg RL. Segmental breast calcifications. American Journal of Roentgenology. 2012 Nov;199(5):W532–542.
    14. Janas MM, Wang E, Love T, Harris AS, Stevenson K, Semmelmann K, et al. Reduced expression of ribosomal proteins relieves microRNA-mediated repression. Mol Cell. 2012 Apr 27;46(2):171–86.
    15. Levy C, Khaled M, Iliopoulos D, Janas MM, Schubert S, Pinner S, Chen PH, et al. Intronic miR-211 assumes the tumor suppressive function of its host gene in melanoma. Mol Cell. 2010 Dec 10;40(5):841-849.
    16. Levy C, Khaled M, Robinson KC, Veguilla RA, Chen PH, Yokoyama S, et al. Lineage-specific transcriptional regulation of DICER by MITF in melanocytes. Cell. 2010 Jun 11;141(6):994-1005.
    17. Ramappa AJ, Chen PH, Hawkins RJ, Noonan T, Hackett T, Sabick MB, et al. Anterior shoulder forces in professional and Little League pitchers. J Pediatr Orthop. 2010 Feb;30(1):1-7.
    18. Reed RD, Chen PH, Nijhout HF. Cryptic variation in butterfly eyespot development: the importance of sample size in gene expression studies. Evol Dev. 2007 Feb;9(1):2-9.

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